The DREAMS project aims for an AIDS-free generation. Across sub-Saharan Africa, girls and young women make up 71% of new HIV infections among the adolescent population. Launched in February 2016, the DREAMS (Determined, Resilient, Empowered, AIDS-free, Mentored, and Safe) partnership aims to reduce the high incidence of HIV infections among girls and young women in ten countries (Kenya, Lesotho, Malawi, Mozambique, South Africa, Swaziland, Tanzania, Uganda, Zambia, and Zimbabwe) through integrated efforts. DREAMS’ holistic approach includes a core package inclusive of health and issues outside of the health sector and addresses the structural drivers that impact HIV risk in girls, such as poverty, gender inequality, sexual violence, and education. The following six areas serve as a focus for the project: strengthening capacity for service delivery; keeping girls in secondary school; linking men to services; supporting pre-exposure prophylaxis; providing a bridge to employment; and applying data to increase impact.